However, it is extremely important that medications are tapered slowly and under the supervision of a physician. This can stop your child’s body from overproducing cortisol that is causing Cushing’s symptoms. If your child has an autoimmune disorder and is taking long-term glucocorticoid medication, it may be necessary to change the dosage and frequency of the medication. This may be appropriate for children who have abnormalities in the adrenal or pituitary glands. Your child’s doctor may prescribe medications that block the excessive production of certain hormones. Because there are different causes of Cushing’s syndrome, treatment options vary. The goal of treatment is to stop or remove the source of the extra cortisol in your child’s body. Our team of specialists is here to support your family every step of the way as your child grows.

Cushing’s syndrome may require lifelong treatment. In the Adrenal and Puberty Center at CHOP, our team will work with your family to develop an individualized plan to treat and monitor your child’s condition.

Computed tomography (CT) scan, which uses a combination of X-rays and computer technology to examine bones and produces cross-sectional images ('slices') of the body.

Your child is exposed to no radiation during an MRI.

Magnetic resonance imaging (MRI), which uses a combination of large magnets, radiofrequencies and a computer to produce detailed images of organs, soft tissues, muscles, ligaments and other structures within the body.

X-rays, which produce images of bones on film.

Corticotropin-releasing hormone stimulation test, which can determine whether the extra cortisol your child’s body is producing is the result of a tumor in the adrenal or pituitary gland.

The test measures whether your child’s pituitary gland is producing too much adrenocorticotrophic hormone (ACTH). Your child is given a synthetic glucocorticoid medication, then blood is drawn and tested to determine the cortisol level in the blood. This testing can be done by drawing blood or using a saliva swab inside the cheek. Children with Cushing’s syndrome will have elevated cortisol levels at this time - similar to levels found in most children in the early morning. Most children have very low cortisol levels at midnight when they are sleeping. Urine is collected for 24 hours to measure hormone levels. However, an examination and testing by a skilled pediatric endocrinologist will be needed to confirm the diagnosis. Cushing’s syndrome may be suspected in a child who is abnormally short but continues to gain weight.

Over productive adrenal gland